Artificial intelligence to deep learning: machine intelligence approach for drug discovery
Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …
companies and chemical scientists. However, low efficacy, off-target delivery, time …
A global review on short peptides: frontiers and perspectives
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …
entities via all domains of life and interfere with protein-protein interactions, which are …
Evolutionary-scale prediction of atomic-level protein structure with a language model
Recent advances in machine learning have leveraged evolutionary information in multiple
sequence alignments to predict protein structure. We demonstrate direct inference of full …
sequence alignments to predict protein structure. We demonstrate direct inference of full …
DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks
J Hallgren, KD Tsirigos, MD Pedersen… - BioRxiv, 2022 - biorxiv.org
Transmembrane proteins span the lipid bilayer and are divided into two major structural
classes, namely alpha helical and beta barrels. We introduce DeepTMHMM, a deep …
classes, namely alpha helical and beta barrels. We introduce DeepTMHMM, a deep …
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental …
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), the US data center for the global PDB archive and a founding member of the …
PDB), the US data center for the global PDB archive and a founding member of the …
PubChem in 2021: new data content and improved web interfaces
Abstract PubChem (https://pubchem. ncbi. nlm. nih. gov) is a popular chemical information
resource that serves the scientific community as well as the general public, with millions of …
resource that serves the scientific community as well as the general public, with millions of …
BRENDA, the ELIXIR core data resource in 2021: new developments and updates
The BRENDA enzyme database (https://www. brenda-enzymes. org), established in 1987,
has evolved into the main collection of functional enzyme and metabolism data. In 2018 …
has evolved into the main collection of functional enzyme and metabolism data. In 2018 …
The implications of IDH mutations for cancer development and therapy
CJ Pirozzi, H Yan - Nature reviews Clinical oncology, 2021 - nature.com
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
[PDF][PDF] Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
D Liebschner, PV Afonine, ML Baker… - … Section D: Structural …, 2019 - journals.iucr.org
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …
to determine three-dimensional macromolecular structures, which are required to …
[HTML][HTML] Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines
X Liu, XJ Wang - Journal of Genetics and Genomics, 2020 - ncbi.nlm.nih.gov
Coronaviruses, members of the family Coronaviridae and subfamily Coronavirinae, are
enveloped positive-strand RNA viruses which have spikes of glycoproteins projecting from …
enveloped positive-strand RNA viruses which have spikes of glycoproteins projecting from …