We describe a new basis for the construction of a genetic linkage map of the human
genome. The basic principle of the mapping scheme is to develop, by recombinant DNA …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

The SIR genes are determinants of life span in yeast mother cells. Here we show that life
span regulation by the Sir proteins is independent of their role in nonhomologous end …

Genetic mapping provides a powerful approach to identify genes and biological processes
underlying any trait influenced by inheritance, including human diseases. We discuss the …

Medical genetics was revolutionized during the 1980s by the application of genetic mapping
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …

We describe a general, simple and inexpensive method for the isolation of DNA from
filamentous fungi. Starting from freeze‐dried mycelium 01–015% by weight can be isolated …

The nonrandom distribution of meiotic recombination influences patterns of inheritance and
genome evolution, but chromosomal features governing this distribution are poorly …

▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

▪ Abstract Nineteen single dominant genes (R genes) for resistance to viruses, nematodes,
and fungi have been positioned on the molecular map of potato using DNA markers …

The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the
mating type system. We have found that SIR2 also plays another important role in the cell …