Hyperglycemia and oxidative stress: An integral, updated and critical overview of their metabolic interconnections

P González, P Lozano, G Ros, F Solano - International Journal of …, 2023 - mdpi.com
This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs

I Bjarnason, C Scarpignato, E Holmgren, M Olszewski… - Gastroenterology, 2018 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) can damage the gastrointestinal tract,
causing widespread morbidity and mortality. Although mechanisms of damage involve the …

Paracetamol–An old drug with new mechanisms of action

GW Przybyła, KA Szychowski… - Clinical and Experimental …, 2021 - Wiley Online Library
Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …

Covalent inhibition in drug discovery

AK Ghosh, I Samanta, A Mondal, WR Liu - ChemMedChem, 2019 - Wiley Online Library
Although covalent inhibitors have been used as therapeutics for more than a century, there
has been general resistance in the pharmaceutical industry against their further …

The biosynthesis of enzymatically oxidized lipids

AA Hajeyah, WJ Griffiths, Y Wang, AJ Finch… - Frontiers in …, 2020 - frontiersin.org
Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

A review on plant-based rutin extraction methods and its pharmacological activities

LS Chua - Journal of ethnopharmacology, 2013 - Elsevier
Ethnopharmacological relevance Rutin is a common dietary flavonoid that is widely
consumed from plant-derived beverages and foods as traditional and folkloric medicine …

Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2

B Kaur, P Singh - Bioorganic Chemistry, 2022 - Elsevier
Keeping in view the involvement of inflammation in the pathogenesis of several diseases
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …

Heme enzyme structure and function

TL Poulos - Chemical reviews, 2014 - ACS Publications
Metalloporphyrins are widely used throughout the biosphere, and of these heme (iron
protoporphyrin IX, Figure 1) is one of the most abundant and widely used. Heme shuttles …

[HTML][HTML] Selective COX-2 inhibitors: a review of their structure-activity relationships

A Zarghi, S Arfaei - Iranian journal of pharmaceutical research …, 2011 - ncbi.nlm.nih.gov
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of
cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid …

The biochemistry and medical significance of the flavonoids

BH Havsteen - Pharmacology & therapeutics, 2002 - Elsevier
Flavonoids are plant pigments that are synthesised from phenylalanine, generally display
marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are …