Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation
K Van Roey, B Uyar, RJ Weatheritt, H Dinkel… - Chemical …, 2014 - ACS Publications
The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …
mediate the functions required for cell viability. Specific, context-dependent and tightly …
Predicting the effects of amino acid substitutions on protein function
PC Ng, S Henikoff - Annu. Rev. Genomics Hum. Genet., 2006 - annualreviews.org
Nonsynonymous single nucleotide polymorphisms (nsSNPs) are coding variants that
introduce amino acid changes in their corresponding proteins. Because nsSNPs can affect …
introduce amino acid changes in their corresponding proteins. Because nsSNPs can affect …
SIFT web server: predicting effects of amino acid substitutions on proteins
Abstract The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding
variants on protein function. It was first introduced in 2001, with a corresponding website that …
variants on protein function. It was first introduced in 2001, with a corresponding website that …
Predicting deleterious amino acid substitutions
PC Ng, S Henikoff - Genome research, 2001 - genome.cshlp.org
Many missense substitutions are identified in single nucleotide polymorphism (SNP) data
and large-scale random mutagenesis projects. Each amino acid substitution potentially …
and large-scale random mutagenesis projects. Each amino acid substitution potentially …
Human non‐synonymous SNPs: server and survey
Human single nucleotide polymorphisms (SNPs) represent the most frequent type of human
population DNA variation. One of the main goals of SNP research is to understand the …
population DNA variation. One of the main goals of SNP research is to understand the …
Amino acid properties and consequences of substitutions
MJ Betts, RB Russell - Bioinformatics for geneticists, 2003 - Wiley Online Library
Amino acid properties and consequences of substitutions Page 297 CHAPTER 14 Amino
Acid Properties and Consequences of Substitutions MATTHEW J. BETTS1 and ROBERT B …
Acid Properties and Consequences of Substitutions MATTHEW J. BETTS1 and ROBERT B …
Manganese superoxide dismutase and oxidative stress modulation
G Bresciani, IBM da Cruz… - Advances in clinical …, 2015 - Elsevier
Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production
and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system …
and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system …
SNPs, protein structure, and disease
Z Wang, J Moult - Human mutation, 2001 - Wiley Online Library
Inherited disease susceptibility in humans is most commonly associated with single
nucleotide polymorphisms (SNPs). The mechanisms by which this occurs are still poorly …
nucleotide polymorphisms (SNPs). The mechanisms by which this occurs are still poorly …
Exome sequencing and the genetic basis of complex traits
Exome sequencing and the genetic basis of complex traits | Nature Genetics Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …
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Prediction of deleterious human alleles
Single nucleotide polymorphisms (SNPs) constitute the bulk of human genetic variation,
occurring with an average density of∼ 1/1000 nucleotides of a genotype. SNPs are either …
occurring with an average density of∼ 1/1000 nucleotides of a genotype. SNPs are either …