The immunology of long COVID

DM Altmann, EM Whettlock, S Liu… - Nature Reviews …, 2023 - nature.com
Long COVID is the patient-coined term for the disease entity whereby persistent symptoms
ensue in a significant proportion of those who have had COVID-19, whether asymptomatic …

[HTML][HTML] The neurobiology of long COVID

M Monje, A Iwasaki - Neuron, 2022 - cell.com
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of
people after COVID-19 and represent a major component of the post-acute COVID-19 …

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

SR Stein, SC Ramelli, A Grazioli, JY Chung, M Singh… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction,–
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Unexplained post-acute infection syndromes

J Choutka, V Jansari, M Hornig, A Iwasaki - Nature medicine, 2022 - nature.com
SARS-CoV-2 is not unique in its ability to cause post-acute sequelae; certain acute
infections have long been associated with an unexplained chronic disability in a minority of …

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

M Khan, SJ Yoo, M Clijsters, W Backaert, A Vanstapel… - Cell, 2021 - cell.com
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure …

Neurovascular injury with complement activation and inflammation in COVID-19

MH Lee, DP Perl, J Steiner, N Pasternack, W Li… - Brain, 2022 - academic.oup.com
The underlying mechanisms by which severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) leads to acute and long-term neurological manifestations remains obscure …

[HTML][HTML] Diverse functional autoantibodies in patients with COVID-19

EY Wang, T Mao, J Klein, Y Dai, JD Huck, JR Jaycox… - Nature, 2021 - nature.com
COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by
exaggerated and misdirected host immune responses,,,,–. Although pathological innate …

Nervous system consequences of COVID-19

S Spudich, A Nath - Science, 2022 - science.org
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered a
respiratory pathogen, myriad neurologic complications—including confusion, stroke, and …

Pathogenesis underlying neurological manifestations of long COVID syndrome and potential therapeutics

A Leng, M Shah, SA Ahmad, L Premraj, K Wildi… - Cells, 2023 - mdpi.com
The development of long-term symptoms of coronavirus disease 2019 (COVID-19) more
than four weeks after primary infection, termed “long COVID” or post-acute sequela of …

Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches

J Ahamed, J Laurence - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
SARS-CoV-2–infected individuals may suffer a multi–organ system disorder known as “long
COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC). There are no standard …