Despite enormous advances, cardiovascular disorders are still a major threat to global
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …

In the central nervous system (CNS) there are a greater number of glial cells than neurons
(between five and ten times more). Furthermore, they have a greater number of functions …

The glial environment influences neurological disease progression, yet much of our
knowledge still relies on preclinical animal studies, especially regarding astrocyte …

Background: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused
by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …

BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs)
disease, including brain bleedings and thrombosis that cause neurological disabilities in …

Cerebral cavernous malformation (CCM) is a neurovascular disease that results in various
neurological symptoms. Thrombi have been reported in surgically resected CCM patient …

Atherosclerosis is an important problem in modern medicine, the keys to understanding
many aspects of which are still not available to clinicians. Atherosclerosis develops as a …

Cerebral cavernous malformations (CCMs) are low-flow, hemorrhagic vascular lesions of
the central nervous system of genetic origin, which can cause stroke-like symptoms and …

Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no
currently available therapeutics. Prior evidence suggests that different cell types may play a …

Cerebral cavernous malformations (CCMs) arise when capillaries within the brain enlarge
abnormally, causing the blood–brain barrier (BBB) to break down. The BBB serves as a …