Members of the GroEL/HSP60 protein family have been studied for many years because of
their critical roles as ATP-dependent molecular chaperones, so it might come as a surprise …

Adaption of a single protein to perform multiple independent functions facilitates functional
plasticity of the proteome allowing a limited number of protein-coding genes to perform a …

It is not often realized that the absolute protein specificity is an exception rather than a rule.
Two major kinds of protein multi-specificities are promiscuity and moonlighting. This review …

Moonlighting–the performance of more than one function by a single protein–is becoming
recognized as a common phenomenon with important implications for systems biology and …

Peroxiredoxin 6 (Prdx6) is a Ca 2+-independent intracellular phospholipase A 2 (called
aiPLA 2) that is localized to cytosol, lysosomes, and lysosomal-related organelles. Activity is …

Moonlighting proteins are a subclass of multifunctional proteins whose functions are
unrelated. Although they may play important roles in cells, there has been no large-scale …

Genetic and other variations frequently affect protein functions. Scientific articles can contain
confusing descriptions about which function or property is affected, and in many cases the …

In the past few decades, hundreds of moonlighting proteins have been identified that
perform two or more distinct and physiologically relevant biochemical or biophysical …

Metabolism sustains life through enzyme-catalyzed chemical reactions within the cells of all
organisms. The coupling of catalytic function to the structural organization of enzymes …

The interferon (IFN)‐γ‐activated inhibitor of translation (GAIT) system directs transcript‐
selective translational control of functionally related genes. In myeloid cells, IFN‐γ induces …