Concise review: stem cell trials using companion animal disease models

AM Hoffman, SW Dow - Stem cells, 2016 - academic.oup.com
Studies to evaluate the therapeutic potential of stem cells in humans would benefit from
more realistic animal models. In veterinary medicine, companion animals naturally develop …

Dietary medium chain triglycerides for management of epilepsy: New data from human, dog, and rodent studies

FY Han, L Conboy‐Schmidt, G Rybachuk, HA Volk… - …, 2021 - Wiley Online Library
Many studies show that glucose metabolism in epileptic brain areas can be impaired.
Energy is crucial to maintain normal brain function, including ion and neurotransmitter …

Dogs as a natural animal model of epilepsy

W Löscher - Frontiers in veterinary science, 2022 - frontiersin.org
Epilepsy is a common neurological disease in both humans and domestic dogs, making
dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain …

Translational veterinary epilepsy: A win-win situation for human and veterinary neurology

M Charalambous, A Fischer, H Potschka… - The Veterinary …, 2023 - Elsevier
Epilepsy is a challenging multifactorial disorder with a complex genetic background. Our
current understanding of the pathophysiology and treatment of epilepsy has substantially …

The evolution of the human brain and disease susceptibility

K Pattabiraman, SK Muchnik, N Sestan - Current opinion in genetics & …, 2020 - Elsevier
Evolutionary perspective is critical for understanding human biology, human medicine, and
the traits that make human beings unique. One of the crucial characteristics that sets …

Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1

F Wielaender, R Sarviaho, F James… - Proceedings of the …, 2017 - National Acad Sciences
The clinical and electroencephalographic features of a canine generalized myoclonic
epilepsy with photosensitivity and onset in young Rhodesian Ridgeback dogs (6 wk to 18 …

[HTML][HTML] Pathophysiology of drug-resistant canine epilepsy

H Potschka, A Fischer, W Löscher, HA Volk - The Veterinary Journal, 2023 - Elsevier
Drug resistance continues to be a major clinical problem in the therapeutic management of
canine epilepsies with substantial implications for quality of life and survival times …

Seizure occurrence in dogs under primary veterinary care in the UK: prevalence and risk factors

A Erlen, H Potschka, HA Volk… - Journal of veterinary …, 2018 - Wiley Online Library
Background Primary‐care veterinary clinical records can offer data to determine
generalizable epidemiological data on seizures occurrence in the dog population …

Th17 cell-mediated immune response in a subpopulation of dogs with idiopathic epilepsy

A Knebel, A Kämpe, R Carlson, K Rohn, A Tipold - PLoS One, 2022 - journals.plos.org
Background Canine idiopathic epilepsy (IE) is a common neurological disease with severe
impact on the owner´ s and the dog's quality of life. A subpopulation of dogs with IE does not …

[HTML][HTML] Diagnostic techniques to detect the epileptogenic zone: pathophysiological and presurgical analysis of epilepsy in dogs and cats

D Hasegawa - The Veterinary Journal, 2016 - Elsevier
The use and availability of magnetic resonance imaging (MRI) and other neurosurgical
devices is rapidly increasing in the field of veterinarian medicine. Coincident with these …