Is realistic neuronal modeling realistic?
M Almog, A Korngreen - Journal of neurophysiology, 2016 - journals.physiology.org
Scientific models are abstractions that aim to explain natural phenomena. A successful
model shows how a complex phenomenon arises from relatively simple principles while …
model shows how a complex phenomenon arises from relatively simple principles while …
An Ovol2-Zeb1 mutual inhibitory circuit governs bidirectional and multi-step transition between epithelial and mesenchymal states
T Hong, K Watanabe, CH Ta… - PLoS computational …, 2015 - journals.plos.org
Reversible epithelial-to-mesenchymal transition (EMT) is central to tissue development,
epithelial stemness, and cancer metastasis. While many regulatory elements have been …
epithelial stemness, and cancer metastasis. While many regulatory elements have been …
Code generation in computational neuroscience: a review of tools and techniques
Advances in experimental techniques and computational power allowing researchers to
gather anatomical and electrophysiological data at unprecedented levels of detail have …
gather anatomical and electrophysiological data at unprecedented levels of detail have …
C. elegans AWA olfactory neurons fire calcium-mediated all-or-none action potentials
Q Liu, PB Kidd, M Dobosiewicz, CI Bargmann - Cell, 2018 - cell.com
Neurons in Caenorhabditis elegans and other nematodes have been thought to lack
classical action potentials. Unexpectedly, we observe membrane potential spikes with …
classical action potentials. Unexpectedly, we observe membrane potential spikes with …
Working memory and decision-making in a frontoparietal circuit model
Working memory (WM) and decision-making (DM) are fundamental cognitive functions
involving a distributed interacting network of brain areas, with the posterior parietal cortex …
involving a distributed interacting network of brain areas, with the posterior parietal cortex …
[HTML][HTML] Coupling the modules of EMT and stemness: A tunable 'stemness window'model
Metastasis of carcinoma involves migration of tumor cells to distant organs and initiate
secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal …
secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal …
Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype
Notch signaling pathway mediates cell-fate determination during embryonic development,
wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the …
wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the …
Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype
Metastasis can involve repeated cycles of epithelial-to-mesenchymal transition (EMT) and its
reverse mesenchymal-to-epithelial transition. Cells can also undergo partial transitions to …
reverse mesenchymal-to-epithelial transition. Cells can also undergo partial transitions to …
Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
Epithelial–mesenchymal transition (EMT) plays key roles during embryonic development,
wound healing and cancer metastasis. Cells in a partial EMT or hybrid epithelial …
wound healing and cancer metastasis. Cells in a partial EMT or hybrid epithelial …
Combining a toggle switch and a repressilator within the AC-DC circuit generates distinct dynamical behaviors
Although the structure of a genetically encoded regulatory circuit is an important determinant
of its function, the relationship between circuit topology and the dynamical behaviors it can …
of its function, the relationship between circuit topology and the dynamical behaviors it can …