Autophagy in major human diseases

DJ Klionsky, G Petroni, RK Amaravadi… - The EMBO …, 2021 - embopress.org
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The pathomechanism, antioxidant biomarkers, and treatment of oxidative stress-related eye diseases

YJ Hsueh, YN Chen, YT Tsao, CM Cheng… - International Journal of …, 2022 - mdpi.com
Oxidative stress is an important pathomechanism found in numerous ocular degenerative
diseases. To provide a better understanding of the mechanism and treatment of …

Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers

K Chen, P Lu, NM Beeraka, OA Sukocheva… - Seminars in cancer …, 2022 - Elsevier
Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Autophagy maintains stemness by preventing senescence

L García-Prat, M Martínez-Vicente, E Perdiguero… - Nature, 2016 - nature.com
During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age,
this decline is maximal owing to transition from a normal quiescence into an irreversible …

The role of autophagy in the heart

S Sciarretta, Y Maejima, D Zablocki… - Annual review of …, 2018 - annualreviews.org
Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …

Autophagy mediates degradation of nuclear lamina

Z Dou, C Xu, G Donahue, T Shimi, JA Pan, J Zhu… - Nature, 2015 - nature.com
Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human …

Hypoxia-driven immune escape in the tumor microenvironment

A Vito, N El-Sayes, K Mossman - Cells, 2020 - mdpi.com
The tumor microenvironment is a complex ecosystem comprised of many different cell types,
abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with …

Consensus guidelines for the detection of immunogenic cell death

O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

W B'chir, AC Maurin, V Carraro, J Averous… - Nucleic acids …, 2013 - academic.oup.com
In response to different environmental stresses, eIF2α phosphorylation represses global
translation coincident with preferential translation of ATF4, a master regulator controlling the …