Friend or foe, the role of EGR-1 in cancer

T Li, M Liu, D Pei - Medical Oncology, 2020 - Springer
Abstract Early growth response-1 (EGR-1), also termed NEFI-A and Krox-24, as a multi-
domain protein is implicated in several vital physiological processes, including …

[HTML][HTML] Fear reduced through unconditional stimulus deflation is behaviorally distinct from extinction and differentially engages the amygdala

GR Bonanno, EM Hoxha, PK Robinson… - … Psychiatry Global Open …, 2023 - Elsevier
Background Context fear memory can be reliably reduced by subsequent pairings of that
context with a weaker shock. This procedure shares similarities with extinction learning: both …

Binge-like prenatal ethanol exposure causes impaired cellular differentiation in the embryonic forebrain and synaptic and behavioral defects in adult mice

S Subbanna, BS Basavarajappa - Brain Sciences, 2022 - mdpi.com
An embryo's in-utero exposure to ethanol due to a mother's alcohol drinking results in a
range of deficits in the child that are collectively termed fetal alcohol spectrum disorders …

Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats

NA Heroux, PA Robinson-Drummer, M Kawan… - Behavioural brain …, 2019 - Elsevier
Fetal alcohol exposure leads to severe disruptions in learning and memory involving the
hippocampus and prefrontal cortex in humans. Animal model research on FASD has …

Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats

NA Heroux, CJ Horgan, JB Rosen… - Neurobiology of learning …, 2019 - Elsevier
Neonatal ethanol exposure during the third trimester equivalent of human pregnancy in the
rat significantly impairs hippocampal and prefrontal neurobehavioral functioning. Postnatal …

Egr-1 mRNA expression patterns in the prefrontal cortex, hippocampus, and amygdala during variants of contextual fear conditioning in adolescent rats

WB Schreiber, A Asok, SA Jablonski, JB Rosen… - Brain research, 2014 - Elsevier
We report activation of the immediate-early gene Egr-1 in the lateral amygdala (LA),
hippocampus (CA1), and medial prefrontal cortex (mPFC) 30-min following the training …

Mechanisms of context conditioning in the developing rat

ME Stanton, NJ Murawski, SA Jablonski… - … of Learning and …, 2021 - Elsevier
The article reviews our studies of contextual fear conditioning (CFC) in rats during a period
of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and …

Early Growth Response Gene-1 Deficiency Interrupts TGFβ1 Signaling Activation and Aggravates Neurodegeneration in Experimental Autoimmune Encephalomyelitis …

Y Lan, X Han, F Huang, H Shi, H Wu, L Yang, Z Hu… - Neuroscience …, 2024 - Springer
Early growth response protein 1 (Egr-1) triggers the transcription of many genes involved in
cell growth, differentiation, synaptic plasticity, and neurogenesis. However, its mechanism in …

[图书][B] Prefrontal mechanisms of impaired cognition in a rat model of FASD

NA Heroux - 2020 - search.proquest.com
Abstract Fetal Alcohol Spectrum Disorders (FASDs) represent a significant medical and
societal problem in the United States and abroad, representing a leading preventable cause …

[图书][B] Mechanisms of conjunctive learning in a rat model of fetal alcohol spectrum disorders

SA Jablonski - 2014 - search.proquest.com
Fetal alcohol spectrum disorders (FASDs) describes a continuum of birth defects caused by
maternal intake of alcohol during pregnancy. In humans, developmental alcohol exposure …