Application and interpretation of current autophagy inhibitors and activators

Y Yang, L Hu, H Zheng, C Mao, W Hu… - Acta Pharmacologica …, 2013 - nature.com
Autophagy is the major intracellular degradation system, by which cytoplasmic materials are
delivered to and degraded in the lysosome. As a quality control mechanism for cytoplasmic …

The convergence of radiation and immunogenic cell death signaling pathways

EB Golden, I Pellicciotta, S Demaria… - Frontiers in …, 2012 - frontiersin.org
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of
highly regulated processes. Radiation-induced tumor cell death has been studied …

Adaptive responses to low doses of radiation or chemicals: their cellular and molecular mechanisms

Y Guéguen, A Bontemps, TG Ebrahimian - Cellular and Molecular Life …, 2019 - Springer
This article reviews the current knowledge on the mechanisms of adaptive response to low
doses of ionizing radiation or chemical exposure. A better knowledge of these mechanisms …

Chloroquine, an autophagy inhibitor, potentiates the radiosensitivity of glioma initiating cells by inhibiting autophagy and activating apoptosis

H Ye, M Chen, F Cao, H Huang, R Zhan, X Zheng - BMC neurology, 2016 - Springer
Background Glioblastoma is refractory to conventional treatment, which is combined of
surgery, chemotherapy and radiotherapy. Recent studies have shown that glioma initiating …

Therapeutic interactions of autophagy with radiation and temozolomide in glioblastoma: evidence and issues to resolve

MI Koukourakis, AG Mitrakas… - British journal of cancer, 2016 - nature.com
Glioblastoma is a unique model of non-metastasising disease that kills the vast majority of
patients through local growth, despite surgery and local irradiation. Glioblastoma cells are …

CD47 deficiency confers cell and tissue radioprotection by activation of autophagy

DR Soto-Pantoja, TW Miller, ML Pendrak, WG DeGraff… - Autophagy, 2012 - Taylor & Francis
Accidental or therapeutic exposure to ionizing radiation has severe physiological
consequences and can result in cell death. We previously demonstrated that deficiency or …

Complete activation of autophagic process attenuates liver injury and improves survival in septic mice

CW Lin, S Lo, DS Perng, DBC Wu, PH Lee, YF Chang… - Shock, 2014 - journals.lww.com
The accumulation of autophagosomes in the terminal step of the autophagic process has
recently emerged as a potentially maladaptive process in the septic heart and lung …

Radiation Hormesis to Improve the Quality of Adult Spodoptera litura (Fabr.)

N Vimal, N Angmo, M Sengupta, RK Seth - Insects, 2022 - mdpi.com
Simple Summary Spodoptera litura (Fabr.) is a serious noctuid lepidopteran pest in India
that can be managed using the eco-friendly, radio-genetic inherited sterility (IS) technique …

Atorvastatin Attenuates Radiotherapy‐Induced Intestinal Damage through Activation of Autophagy and Antioxidant Effects

MF Wei, CH Cheng, SY Wen, JC Lin… - Oxidative medicine …, 2022 - Wiley Online Library
Abdominal or pelvic radiotherapy (RT) often results in small intestinal injury, such as
apoptosis of epithelial cells and shortening of the villi. Atorvastatin, a 3‐hydroxy‐3 …

Radiation hormesis: autophagy and other cellular mechanisms

I Szumiel - International journal of radiation biology, 2012 - Taylor & Francis
Purpose: To review the cellular mechanisms of hormetic effects induced by low dose and
low dose rate ionising radiation in model systems, and to call attention to the possible role of …