Blue-light receptors for optogenetics

A Losi, KH Gardner, A Möglich - Chemical reviews, 2018 - ACS Publications
Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies

WF Zuo, Q Pang, X Zhu, QQ Yang, Q Zhao… - Journal of Hematology & …, 2024 - Springer
Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

Harnessing mechanobiology for tissue engineering

S Kim, M Uroz, JL Bays, CS Chen - Developmental cell, 2021 - cell.com
A primary challenge in tissue engineering is to recapitulate both the structural and functional
features of whole tissues and organs. In vivo, patterning of the body plan and constituent …

Signaling pathways in brain ischemia: Mechanisms and therapeutic implications

W Lin, XY Zhao, J Cheng, L Li, Q Jiang… - Pharmacology & …, 2023 - Elsevier
Ischemic stroke occurs when the arteries supplying blood to the brain are narrowed or
blocked, inducing damage to brain tissue due to a lack of blood supply. One effective way to …

Kindlins: roles in development and cancer progression

J Zhan, H Zhang - The International Journal of Biochemistry & Cell …, 2018 - Elsevier
The Kindlins are FERM domain proteins comprising three members (Kindlin-1,-2 and-3)
which are evolutionarily conserved. Kindlins bind with β-integrin cytoplasmic tails and …

Transcriptome-based screening of intracellular pathways and angiogenesis related genes at different stages of thiram induced tibial lesions in broiler chickens

AR Jahejo, D Zhang, S Niu, RA Mangi, A Khan… - BMC genomics, 2020 - Springer
Abstract Background The Tibial dyschondroplasia (TD) in fast-growing chickens is mainly
caused by improper blood circulation. The exact mechanism underlying angiogenesis and …

Integrins: moonlighting proteins in invadosome formation

R Peláez, A Pariente, Á Pérez-Sala, IM Larrayoz - Cancers, 2019 - mdpi.com
Invadopodia are actin-rich protrusions developed by transformed cells in 2D/3D
environments that are implicated in extracellular matrix (ECM) remodeling and degradation …

Ligustrazine recovers thiram-induced tibial dyschondroplasia in chickens: Involvement of new molecules modulating integrin beta 3

K Mehmood, H Zhang, X Jiang, W Yao, X Tong… - Ecotoxicology and …, 2019 - Elsevier
Tetramethyl thiuram disulfide (thiram) is a dithiocarbamate, which is extensively used in
agriculture as pesticide and fungicide for treating grains intended for seed purposes and …

Optogenetic approaches for the spatiotemporal control of signal transduction pathways

MM Kramer, L Lataster, W Weber… - International Journal of …, 2021 - mdpi.com
Biological signals are sensed by their respective receptors and are transduced and
processed by a sophisticated intracellular signaling network leading to a signal-specific …

Label-free single-molecule quantification of rapamycin-induced FKBP–FRB dimerization for direct control of cellular mechanotransduction

Y Wang, SFH Barnett, S Le, Z Guo, X Zhong… - Nano …, 2019 - ACS Publications
Chemically induced dimerization (CID) has been applied to study numerous biological
processes and has important pharmacological applications. However, the complex multistep …