The term auto-inflammatory disease has been proposed to describe a group of disorders
characterized by attacks of seemingly unprovoked inflammation without significant levels of …

Inflammasomes are multiprotein complexes that can sense pathogen‐associated molecular
patterns and damage‐associated molecular signals. They are involved in the initiation and …

Background: Pyrin is a newly recognised intracellular regulator of inflammation, and
mutations in MEFV, the gene encoding pyrin, are the cause of familial Mediterranean fever …

OBJECTIVE:: Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy (PFAPA)
syndrome is a sporadic disease, characterized by periodic attacks of inflammation …

Compelling epidemiologic and molecular data indicate that genes play a primary role in
determining who is at risk for developing multiple sclerosis (MS), how the disease …

Major advancements have been achieved in our ability to diagnose multiple sclerosis (MS)
and to commence treatment intervention with agents that can favorably affect the disease …

Microbial agents can aggravate inflammatory diseases, such as multiple sclerosis (MS) and
its animal model, experimental autoimmune encephalomyelitis (EAE). An example is …

Background: Behcet's disease (BD) is an inflammatory disorder of unknown cause,
associated with vasculitis. Arterial or venous thrombosis occurs in about 25% of BD patients …

OBJECTIVES Crohn's disease (CD) has been reported to be more frequent among non-
Ashkenazi Jewish patients suffering from familial Mediterranean fever (FMF). Interestingly …

Neutrophils are essential to a healthy life, yet pose a threat if improperly controlled.
Neutrophil perversion is well documented in a variety of inflammatory disorders (eg arthritis …