Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction

J Hong, S Kumar - Clinical Science, 2023 - portlandpress.com
Fetal growth restriction (FGR) leading to low birth weight (LBW) is a major cause of neonatal
morbidity and mortality worldwide. Normal placental development involves a series of highly …

[HTML][HTML] Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy

Q Li, A Sharkey, M Sheridan, E Magistrati… - Cell Stem Cell, 2024 - cell.com
In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is
critical for successful pregnancy. Evidence suggests that this process is regulated by uterine …

Genetic associations of circulating cardiovascular proteins with gestational hypertension and preeclampsia

A Schuermans, B Truong, M Ardissino… - JAMA …, 2024 - jamanetwork.com
Importance Hypertensive disorders of pregnancy (HDPs), including gestational hypertension
and preeclampsia, are important contributors to maternal morbidity and mortality worldwide …

Does the use of angiogenic biomarkers for the management of preeclampsia and fetal growth restriction improve outcomes?: Challenging the current status quo

RR Zegarra, T Ghi, C Lees - European Journal of Obstetrics & Gynecology …, 2024 - Elsevier
Monitoring and timing of delivery in preterm preeclampsia and fetal growth restriction is one
of the biggest challenges in Obstetrics. Finding the optimal time of delivery of these fetuses …

[HTML][HTML] Maternal vitamin D status, fetal growth patterns, and adverse pregnancy outcomes in a multisite prospective pregnancy cohort

C Beck, NR Blue, RM Silver, M Na, WA Grobman… - The American Journal of …, 2024 - Elsevier
Background Few studies have examined maternal vitamin D status and fetal growth patterns
across gestation. Furthermore, time points in pregnancy at which maternal vitamin D status …

[HTML][HTML] Maternal serum levels of soluble fms-like tyrosine kinase-1 and placental growth factor at 20 and 28 weeks of gestational age and the risk of spontaneous …

U Sovio, F Gaccioli, E Cook… - American Journal of …, 2023 - Elsevier
Background Spontaneous preterm birth is the endpoint of multiple different
pathophysiological pathways. Fetal growth restriction, assessed by serial ultrasonic fetal …

Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy

P Greenland, MR Segal, RB McNeil, CB Parker… - JAMA …, 2024 - jamanetwork.com
Importance There is no consensus regarding the best method for prediction of hypertensive
disorders of pregnancy (HDP), including gestational hypertension and preeclampsia …

Potential of plasma inflammatory and angiogenic mediators for predicting spontaneous preterm delivery, intraamniotic infection/inflammation, and composite neonatal …

HJ Kim, KH Park, E Joo, MJ Lee… - American Journal of …, 2024 - Wiley Online Library
Problem To assess the potential of five inflammatory and six angiogenic/antiangiogenic
plasma proteins for predicting imminent spontaneous preterm delivery (SPTD;≤ 14 days of …

Interpretable machine learning to predict adverse perinatal outcomes: examining marginal predictive value of risk factors during pregnancy

SJ Lee, GGP Garcia, KK Stanhope, MH Platner… - American Journal of …, 2023 - Elsevier
BACKGROUND The timely identification of nulliparas at high risk of adverse fetal and
neonatal outcomes during pregnancy is crucial for initiating clinical interventions to prevent …

Association between adverse pregnancy outcome and placental biomarkers in the first trimester: A prospective cohort study

U Sovio, F Gaccioli, E Cook… - … Journal of Obstetrics …, 2024 - Wiley Online Library
Objective To determine the inter‐relationships between five first‐trimester biomarkers
(pregnancy associated plasma protein A [PAPP‐A], alpha‐fetoprotein [AFP], beta human …