Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The liver has a multitude of functions which are necessary to maintain whole body
homeostasis. This requires that various metabolic pathways can run in parallel in the most …

Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of
disability. Characterized by degradation of articular cartilage, synovial inflammation, and …

Osteoarthritis (OA) is a common, painful disease. Currently OA is incurable, and its etiology
largely unknown, partly due to limited understanding of OA as a whole-joint disease. Here …

Articular cartilage is a highly specialized tissue whose remarkable properties of
deformability, resistance to mechanical loading, and low-friction gliding are essential to joint …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading
articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …