Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …

The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly
dysregulated in human malignancies by processes driven by RAS or RAF oncogenes …

Background The extracellular matrix (ECM) and cancer-associated fibroblasts (CAFs) play
major roles in tumor progression, metastasis, and the poor response of many solid tumors to …

Cancer‐associated fibroblasts (CAFs) are heterogeneous stromal cells present in the tumor
microenvironment (TME), which play a critical role in gastric cancer (GC) progression. Here …

Cancer is a heterogeneous disease. Although both tumor metabolism and tumor immune
microenvironment are recognized as driving factors in tumorigenesis, the relationship …

Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, but its
clinical benefit is limited in advanced gastric cancer (GC). Cancer-associated fibroblasts …

Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite
comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic …

Simple Summary Tumor cells struggle to survive following treatment. The struggle ends in
either of two ways. The drug combination used for the treatment blocks the proliferation of …

Resistance to targeted therapy remains a major clinical challenge in melanoma. To uncover
resistance mechanisms, we perform single-cell RNA sequencing on fine-needle aspirates …