Cognitive dysfunctions represent a core feature of schizophrenia-spectrum disorders due to
their presence throughout different illness stages and their impact on functioning …

Cognitive impairment is a hallmark of schizophrenia and a robust predictor of functional
outcomes. Impairments are found in all phases of the illness and are only moderately …

Cognitive impairments are pervasive and disabling features of schizophrenia. Targeted
cognitive training (TCT) is a “bottom-up” cognitive remediation intervention with efficacy for …

Methods Participants in the COGS-2 study have previously been described, including
inclusion and exclusion criteria (29). Participants were either healthy control subjects (HCS …

Background Psychiatry aspires to the molecular understanding of its disorders and, with that
knowledge, to precision medicine. Research supporting such goals in the dimension of …

The uncompetitive low-affinity NMDA receptor antagonist, memantine, acutely increases
electrophysiological measures of auditory information processing in both healthy subjects …

ASP4345, a novel dopamine D1 receptor positive allosteric modulator, is being evaluated
for the treatment of cognitive impairment associated with schizophrenia (CIAS). This phase 1 …

Auditory-based targeted cognitive training (ATCT) programs are emerging pro-cognitive
therapeutic interventions which aim to improve auditory processing to attenuate cognitive …

Chronic psychotic disorders, including schizophrenia (SZ), are highly heterogeneous at
many levels of analysis, from genetics to clinical presentation and treatment sensitivity. This …

Patients with schizophrenia exhibit disrupted thalamocortical connections that relate to
aspects of symptoms and deficits in cognition. Targeted cognitive training (TCT) of the …