Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities

X Jiang, K Wu, R Bai, P Zhang, Y Zhang - European Journal of Medicinal …, 2022 - Elsevier
Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

Antitumoral activity of quinoxaline derivatives: A systematic review

M Montana, F Mathias, T Terme, P Vanelle - European journal of medicinal …, 2019 - Elsevier
Cancer is a leading cause of death and a major health problem worldwide. While many
effective anticancer agents are available, the majority of drugs currently on the market are …

Visible-light-induced four-component difunctionalization of alkenes to construct phosphorodithioate-containing quinoxalin-2 (1H)-ones

XM Chen, L Song, J Pan, F Zeng, Y Xie, W Wei… - Chinese Chemical …, 2024 - Elsevier
A facile visible-light-induced 1, 2, 3, 5-tetrakis (carbazol-9-yl)-4, 6-dicyanobenzene (4CzIPN)
catalyzed four-component reaction of alkenes, quinoxalin-2 (1H)-ones, P 4 S 10 and …

Visible-light-induced three-component reaction of quinoxalin-2 (1H)-ones, alkenes and CF3SO2Na leading to 3-trifluoroalkylated quinoxalin-2 (1H)-ones

N Meng, Y Lv, Q Liu, R Liu, X Zhao, W Wei - Chinese Chemical Letters, 2021 - Elsevier
A facile and metal-free visible-light-enabled three-component reaction of quinoxalin-2 (1H)-
ones, alkenes and CF 3 SO 2 Na has been developed under air at room temperature. This …

Electrochemically dehydrogenative C–H/P–H cross-coupling: effective synthesis of phosphonated quinoxalin-2 (1 H)-ones and xanthenes

KJ Li, YY Jiang, K Xu, CC Zeng, BG Sun - Green Chemistry, 2019 - pubs.rsc.org
An efficient electrochemical approach for the C (sp2)–H phosphonation of quinoxalin-2 (1H)-
ones and C (sp3)–H phosphonation of xanthenes has been developed. The chemistry was …

New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis

NA Alsaif, MA Dahab, MM Alanazi, AJ Obaidullah… - Bioorganic …, 2021 - Elsevier
Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxalin-4 (5H)-one and [1, 2, 4] triazolo [4,
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …

Visible-light-promoted direct C–H/S–H cross-coupling of quinoxalin-2 (1 H)-ones with thiols leading to 3-sulfenylated quinoxalin-2 (1 H)-ones in air

LY Xie, YL Chen, L Qin, Y Wen, JW Xie… - Organic Chemistry …, 2019 - pubs.rsc.org
A new and efficient visible-light-mediated strategy has been developed for the synthesis of 3-
sulfenylated quinoxalin-2 (1H)-ones via direct C–H sulfenylation of quinoxalin-2 (1H)-ones …

Visible-light-promoted acridine red catalyzed aerobic oxidative decarboxylative acylation of α-oxo-carboxylic acids with quinoxalin-2 (1 H)-ones

P Bao, F Liu, Y Lv, H Yue, JS Li, W Wei - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
A mild and facile visible-light-mediated strategy has been proposed for the synthesis of 3-
acyl quinoxalin-2 (1H)-ones through acridine red catalyzed aerobic oxidative …

Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers

MM Alanazi, IH Eissa, NA Alsaif… - Journal of Enzyme …, 2021 - Taylor & Francis
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …

Electrochemical decarboxylative C3 alkylation of quinoxalin-2 (1 H)-ones with N-hydroxyphthalimide esters

K Niu, L Song, Y Hao, Y Liu, Q Wang - Chemical Communications, 2020 - pubs.rsc.org
We have developed a protocol for electrochemical decarboxylative C3 alkylation of a wide
range of quinoxalin-2 (1H)-ones under metal-and additive-free conditions. N …