Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …

Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Abstract Objective To update the “Evaluation and Treatment of Hirsutism in Premenopausal
Women: An Endocrine Society Clinical Practice Guideline,” published by the Endocrine …

Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid
structures and measuring steroid concentrations in body fluids. The molecular biology …

The adrenal cortex produces dozens of steroids having varying degrees of glucocorticoid,
mineralocorticoid, and androgenic activity. Cortisol, the principal glucocorticoid, and …

Castration resistant prostate cancer (CRPC) remains androgen dependant despite castrate
levels of circulating testosterone following androgen deprivation therapy, the first line of …

Bile acids (BAs) and glucocorticoids are steroid hormones derived from cholesterol that are
important signaling molecules in humans and other vertebrates. Hydroxysteroid …

Context Androgen excess in women is predominantly due to underlying polycystic ovary
syndrome (PCOS). However, there is a lack of clarity regarding patterns and severity of …

Context The human adrenal is the dominant source of androgens in castration-resistant
prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone …

Androgens such as testosterone and dihydrotestosterone (DHT) are essential for male
sexual development, masculinisation, and fertility. Testosterone is produced via the …