The synthetic and therapeutic expedition of isoxazole and its analogs

N Agrawal, P Mishra - Medicinal Chemistry Research, 2018 - Springer
Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …

Oxazole and isoxazole: From one-pot synthesis to medical applications

A Thakur, M Verma, R Bharti, R Sharma - Tetrahedron, 2022 - Elsevier
N, O-containing five-membered heterocycles especially oxazole and isoxazole, have widely
been found in many natural products and drugs with relevant medicinal and pharmaceutical …

Molecular docking studies and biological evaluation of isoxazole-carboxamide derivatives as COX inhibitors and antimicrobial agents

M Hawash, N Jaradat, M Abualhasan, MT Qaoud… - 3 Biotech, 2022 - Springer
Non-steroidal anti-inflammatory drugs (NSAIDs) are considered one of the most commonly
used medications globally. Seventeen isoxazole-containing compounds with various …

Chalcones as Versatile Synthons for the Synthesis of 5-and 6-membered Nitrogen Heterocycles

H MT Albuquerque, C MM Santos… - Current Organic …, 2014 - ingentaconnect.com
Chalcones belong to the flavonoid family which constitutes one of the major classes of
naturally occurring oxygen heterocyclic compounds. The α, β-unsaturated carbonyl system …

Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea …

SD Joshi, SR Dixit, MN Kirankumar… - European journal of …, 2016 - Elsevier
We report here the synthesis, antibacterial and antitubercular evaluation of 61 novel pyrrolyl
derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties. Molecular docking …

[PDF][PDF] Isoxazole–a potent pharmacophore

KV Chikkula, S Raja - International Journal of Pharmacy and …, 2017 - academia.edu
Isoxazole is an azole with an oxygen atom next to the nitrogen. Isoxazole rings are found in
some natural products, such as ibotenic acid and also found in a number of drugs, including …

[HTML][HTML] Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl …

BV Kendre, MG Landge, SR Bhusare - Arabian Journal of Chemistry, 2019 - Elsevier
A new series of pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine
derivatives were prepared by the multi-component cyclo-condensation reaction of 1-phenyl …

Recent progress in the synthesis of isoxazoles

DX Duc, VC Dung - Current Organic Chemistry, 2021 - ingentaconnect.com
Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds with one
oxygen atom and one nitrogen atom at adjacent positions. These compounds have a broad …

Green multicomponent synthesis, antimicrobial and antioxidant evaluation of novel 5-amino-isoxazole-4-carbonitriles

H Beyzaei, M Kamali Deljoo, R Aryan… - Chemistry Central …, 2018 - Springer
Background Design and synthesis of new inhibitor agents to deal with pathogenic
microorganisms is expanding. In this project, an efficient, environmentally friendly …

Isoxazole derivatives of silatrane: synthesis, characterization, in silico ADME profile, prediction of potential pharmacological activity and evaluation of antimicrobial …

SN Adamovich, EV Kondrashov… - Applied …, 2020 - Wiley Online Library
A new family of mono‐(3a‐h) and bis‐(4a‐g) isoxazole‐bridged silatranes has been
synthesized by the reaction of 3‐aminopropylsilatrane (1) and 3‐substituted 5‐chloro …