Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy

B Toledo, L Zhu Chen, M Paniagua-Sancho… - Journal of hematology & …, 2024 - Springer
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy

M Tang, B Chen, H Xia, M Pan, R Zhao, J Zhou… - Nature …, 2023 - nature.com
Abstract Tumour-associated macrophages (TAMs), as one of the most abundant tumour-
infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune …

[HTML][HTML] From crypts to cancer: a holistic perspective on colorectal carcinogenesis and therapeutic strategies

E Gharib, GA Robichaud - International journal of molecular sciences, 2024 - mdpi.com
Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …

Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs

S Shao, H Miao, W Ma - Frontiers in Immunology, 2023 - frontiersin.org
Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME),
influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit …

[HTML][HTML] Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer

W Zeng, H Liu, Y Mao, S Jiang… - International …, 2024 - spandidos-publications.com
Globally, colorectal cancer (CRC) is the third most common type of cancer. CRC has no
apparent symptoms in the early stages of disease, and most patients receive a confirmed …

[HTML][HTML] Insights into CSF-1R expression in the tumor microenvironment

C Tomassetti, G Insinga, F Gimigliano, A Morrione… - Biomedicines, 2024 - mdpi.com
The colony-stimulating factor 1 receptor (CSF-1R) plays a pivotal role in orchestrating
cellular interactions within the tumor microenvironment (TME). Although the CSF-1R has …

Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy

S Xu, Q Wang, W Ma - Cytokine & Growth Factor Reviews, 2024 - Elsevier
Navigating the intricate landscape of the tumor microenvironment (TME) unveils a pivotal
arena for cancer therapeutics, where cytokines and soluble mediators emerge as double …

Tumor-associated macrophages in colorectal cancer metastasis: molecular insights and translational perspectives

S Hou, Y Zhao, J Chen, Y Lin, X Qi - Journal of Translational Medicine, 2024 - Springer
Metastasis is the leading cause of high mortality in colorectal cancer (CRC), which is not
only driven by changes occurring within the tumor cells, but is also influenced by the …

Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring

J Berthe, P Poudel, FJ Segerer, EC Jennings… - Frontiers in …, 2024 - frontiersin.org
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with
improved survival of cancer patients and response to immunotherapies. However, conflicting …

Low CXCL11 expression is indicative of poor prognosis in rectal cancer patients undergoing preoperative chemoradiotherapy: a retrospective cohort study

CL Chou, CY Lin, WS Li, SW Lee, CC Yang, YF Tian… - Virchows Archiv, 2024 - Springer
Methods The mRNA level (by transcriptomic profiling) and protein expression (by
immunohistochemical staining) of CXC motif chemokine ligand 11 (CXCL11) were …