Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Unraveling the complex roles of macrophages in obese adipose tissue: an overview

C Peng, J Chen, R Wu, H Jiang, J Li - Frontiers of medicine, 2024 - Springer
Macrophages, a heterogeneous population of innate immune cells, exhibit remarkable
plasticity and play pivotal roles in coordinating immune responses and maintaining tissue …

Deletion of spinophilin promotes white adipocyte browning

W Gou, H Wei, L Swaby, E Green, H Wang - Pharmaceuticals, 2023 - mdpi.com
Browning of white adipose tissue (WAT) is suggested as a promising therapeutic approach
to induce energy expenditure and counteract obesity and its associated complications …

The endoplasmic reticulum stress protein GRP94 modulates cathepsin L activity in M2 macrophages in conditions of obesity-associated inflammation and contributes …

F Wang, V Baverel, K Chaumonnot… - International Journal of …, 2024 - nature.com
Background/objectives Adipose tissue macrophages (ATM) are key actors in the
pathophysiology of obesity-related diseases. They have a unique intermediate M2-M1 …

[PDF][PDF] Myeloid endoplasmic reticulum resident chaperone GP96 facilitates inflammation and steatosis in alcohol‐associated liver disease

A Ratna, A Lim, Z Li, J Argemi, R Bataller… - Hepatology …, 2021 - Wiley Online Library
Cellular stress–mediated chaperones are linked to liver macrophage activation and
inflammation in alcohol‐associated liver disease (ALD). In this study, we investigate the role …

3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue

SM Woo, NA Nguyen, JE Seon, J Jang, SM Yee… - Molecules, 2023 - mdpi.com
Phloretin and its glycoside phlorizin have been reported to prevent obesity induced by high-
fat diet (HFD), but the effect of 3-OH phloretin, a catechol metabolite of phloretin, has not …

Endotoxin-induced alterations of adipose tissue function: a pathway to bovine metabolic stress

M Chirivi, GA Contreras - Journal of Animal Science and Biotechnology, 2024 - Springer
During the periparturient period, dairy cows exhibit negative energy balance due to limited
appetite and increased energy requirements for lactogenesis. The delicate equilibrium …

Role of adiposopathy and physical activity in cardio-metabolic disorder diseases

X Su, D Chang - Clinica Chimica Acta, 2020 - Elsevier
Positive calorie balance disrupts the function of visceral adipose tissue, including the
cardiac adipose tissue and the perivascular adipose tissue. The inflammatory and hormonal …

Trans 10, cis 12-conjugated linoleic acid in low concentration reduces while in high concentration enhances adipocyte metabolism but effectively improves hepatic …

Y Rao, S Yu, L Liang, Q Wang, J Lu, B Wang… - The Journal of Nutritional …, 2025 - Elsevier
Abstract Trans 10, cis 12-conjugated linoleic acid (t10c12-CLA)-producing mice were used
to investigate the antiobesity of obese males. Compared to wild-type littermates, high …

The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases

S Ryu, EK Lee - International Journal of Molecular Sciences, 2024 - mdpi.com
The pancreas is an organ with both exocrine and endocrine functions, comprising a highly
organized and complex tissue microenvironment composed of diverse cellular and non …