Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity,
pH, and radiation that prove intolerable to most life. Many environmental extremes raise the …

The DNA repair endonuclease EndoMS/NucS is highly conserved in Archaea and
Actinobacteria. This enzyme is able to recognize and cleave dsDNA carrying a mismatched …

The common mismatch repair system processed by MutS and MutL and their homologs was
identified in Bacteria and Eukarya. However, no evidence of a functional MutS/L homolog …

The DNA repair mechanisms of hyperthermophiles can provide important insights for
understanding how genetic information is maintained under extreme environments. Recent …

Hyperthermophilic Archaea (HA) thrive in high temperature environments and their genome
is facing severe stability challenge due to the increased DNA damage levels caused by high …

Sliding clamps play an essential role in coordinating protein activity in DNA metabolism in
all three domains of life. In eukaryotes and archaea, the sliding clamp is PCNA (proliferating …

In this thesis, EGF, CPεT and transferrin receptors were labeled with luminescent
nanoparticles,, and were tracked both in their local environment in the cell membrane and …