Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

[HTML][HTML] Understanding the role and impact of poly (ethylene glycol)(PEG) on nanoparticle formulation: Implications for COVID-19 vaccines

E Padín-González, P Lancaster, M Bottini… - … in bioengineering and …, 2022 - frontiersin.org
Poly (ethylene glycol)(PEG) is a widely used polymer in a variety of consumer products and
in medicine. PEGylation refers to the conjugation of PEG to drugs or nanoparticles to …

[HTML][HTML] In silico prediction of protein binding affinities onto core–shell PEGylated noble metal nanoparticles for rational design of drug nanocarriers

J Subbotina, I Rouse, V Lobaskin - Nanoscale, 2023 - pubs.rsc.org
Polymer-coated nanoparticles (NP) are commonly used as drug carriers or theranostic
agents. Their uptake rates are modulated by the interactions with essential serum proteins …

Nanoparticle biomolecular corona-based enrichment of plasma glycoproteins for N-glycan profiling and application in biomarker discovery

DN Trinh, RA Gardner, AN Franciosi, C McCarthy… - ACS …, 2022 - ACS Publications
Biomolecular corona formation has emerged as a recurring and important phenomenon in
nanomedicine that has been investigated for potential applications in disease diagnosis. In …

Mucosomes: Intrinsically Mucoadhesive Glycosylated Mucin Nanoparticles as Multi‐Drug Delivery Platform

C Butnarasu, P Petrini, F Bracotti, L Visai… - Advanced …, 2022 - Wiley Online Library
Mucus is a complex barrier for pharmacological treatments and overcoming it is one of the
major challenges faced during transmucosal drug delivery. To tackle this issue, a novel …

Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding

A Ahmad, PG Georgiou, A Pancaro, M Hasan… - Nanoscale, 2022 - pubs.rsc.org
Upon exposure to biological fluids, the fouling of nanomaterial surfaces results in non-
specific capture of proteins, which is particularly important when in contact with blood for in …

Formation and detection of biocoronas in the food industry and their fate in the human body

Q Wu, M Niu, C Zhou, Y Wang, J Xu, L Shi… - Food Research …, 2023 - Elsevier
The rapid advancement of nanotechnology has opened up new avenues for applications in
all stages of the food industry. Over the past decade, extensive research has emphasized …

Competition at the Bio-nano Interface: A Protein, a Polysaccharide, and a Fatty Acid Adsorb onto Magnetic Nanoparticles

L Abarca-Cabrera, L Xu, S Berensmeier… - ACS Applied Bio …, 2022 - ACS Publications
Magnetic nanoparticles are an attractive bioseparation tool due to their magnetic
susceptibility and high adsorption capacity for different types of molecules. A major …

Biomolecular Corona of Gold Nanoparticles: The Urgent Need for Strong Roots to Grow Strong Branches

L Boselli, V Castagnola, A Armirotti, F Benfenati… - Small, 2024 - Wiley Online Library
Gold nanoparticles (GNPs) are largely employed in diagnostics/biosensors and are among
the most investigated nanomaterials in biology/medicine. However, few GNP‐based …

Silver nanoparticle interactions with glycated and non-glycated human serum albumin mediate toxicity

HY Park, C Chung, MK Eiken, KV Baumgartner… - Frontiers in …, 2023 - frontiersin.org
Introduction: Biomolecules bind to and transform nanoparticles, mediating their fate in
biological systems. Despite over a decade of research into the protein corona, the role of …