Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

The role of astrocytes in the central nervous system focused on BK channel and heme oxygenase metabolites: a review

Y Kim, J Park, YK Choi - Antioxidants, 2019 - mdpi.com
Astrocytes outnumber neurons in the human brain, and they play a key role in numerous
functions within the central nervous system (CNS), including glutamate, ion (ie, Ca2+, K+) …

Astrocyte–neuron networks: a multilane highway of signaling for homeostatic brain function

S Mederos, C González-Arias, G Perea - Frontiers in synaptic …, 2018 - frontiersin.org
Research on glial cells over the past 30 years has confirmed the critical role of astrocytes in
pathophysiological brain states. However, most of our knowledge about astrocyte …

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

A Verkhratsky, M Augusto-Oliveira, A Pivoriūnas… - … -European Journal of …, 2021 - Springer
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System

AS Kshatri, A Gonzalez-Hernandez… - Frontiers in molecular …, 2018 - frontiersin.org
Within the potassium ion channel family, calcium activated potassium (KCa) channels are
unique in their ability to couple intracellular Ca2+ signals to membrane potential variations …

Potassium channel gain of function in epilepsy: an unresolved paradox

Z Niday, AV Tzingounis - The Neuroscientist, 2018 - journals.sagepub.com
Exome and targeted sequencing have revolutionized clinical diagnosis. This has been
particularly striking in epilepsy and neurodevelopmental disorders, for which new genes or …

Astrocyte-neuron signaling in synaptogenesis

L Shan, T Zhang, K Fan, W Cai, H Liu - Frontiers in cell and …, 2021 - frontiersin.org
Astrocytes are the key component of the central nervous system (CNS), serving as pivotal
regulators of neuronal synapse formation and maturation through their ability to dynamically …

Astrocyte culture models: Molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells

F Galland, M Seady, J Taday, SS Smaili… - Neurochemistry …, 2019 - Elsevier
The understanding of the physiology of astrocytes and their role in brain function progresses
continuously. Primary astrocyte culture is an alternative method to study these cells in an …

Diversity of astroglial responses across human neurodegenerative disorders and brain aging

I Ferrer - Brain Pathology, 2017 - Wiley Online Library
Astrogliopathy refers to alterations of astrocytes occurring in diseases of the nervous system,
and it implies the involvement of astrocytes as key elements in the pathogenesis and …

Astrocyte adaptation in Alzheimer's disease: a focus on astrocytic P2X7R

P Beltran-Lobo, MJ Reid… - Essays in …, 2023 - portlandpress.com
Astrocytes are key homeostatic and defensive cells of the central nervous system (CNS).
They undertake numerous functions during development and in adulthood to support and …