Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …
central to the balance between immune tolerance and immune rejection. Th cells adopt …
The road to elimination: current state of schistosomiasis research and progress towards the end game
P Ogongo, RK Nyakundi, GK Chege… - Frontiers in …, 2022 - frontiersin.org
The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …
schistosomiasis as a public health problem. To date, control strategies have focused on …
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
Efficient and precise single-cell reference atlas mapping with Symphony
Recent advances in single-cell technologies and integration algorithms make it possible to
construct comprehensive reference atlases encompassing many donors, studies, disease …
construct comprehensive reference atlases encompassing many donors, studies, disease …
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …
Characterizing cellular heterogeneity in chromatin state with scCUT&Tag-pro
Technologies that profile chromatin modifications at single-cell resolution offer enormous
promise for functional genomic characterization, but the sparsity of the measurements and …
promise for functional genomic characterization, but the sparsity of the measurements and …
Co-varying neighborhood analysis identifies cell populations associated with phenotypes of interest from single-cell transcriptomics
As single-cell datasets grow in sample size, there is a critical need to characterize cell states
that vary across samples and associate with sample attributes, such as clinical phenotypes …
that vary across samples and associate with sample attributes, such as clinical phenotypes …
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate
T cells acquire a regulatory phenotype when their T cell antigen receptors (TCRs)
experience an intermediate-to high-affinity interaction with a self-peptide presented via the …
experience an intermediate-to high-affinity interaction with a self-peptide presented via the …
Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis
A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) that we refer to as
'resisters'(RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite …
'resisters'(RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite …
Methods and insights from single-cell expression quantitative trait loci
Recent advancements in single-cell technologies have enabled expression quantitative trait
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …