The p53 tumor suppressor gene is inactivated in human tumors by several distinct
mechanisms. The best characterized inactivation mechanisms are:(i) gene mutation;(ii) p53 …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of
Mdm2 is partially explained by the inhibition of the activity of the tumor suppressor protein …

Besides well‐known risk factors such as tobacco use and alcohol consumption, oncogenic
human papillomavirus (HPV) infection also has recently been suggested to promote head …

Both p53 and ceramide have been implicated in the regulation of growth suppression. p53
has been proposed as the" guardian of the genome" and ceramide has been suggested as …

Loss of cell cycle control and increased genomic instability are characteristics of most tumor
cells. Activation of proto-oncogenes that promote cell growth in combination with the …

The p53 tumor suppressor gene lies at the crossroads of multiple cellular response
pathways that control a cell's fate in response to endogenous or exogenous stresses …

Lung cancer represents the leading cause of cancer-related death in developed countries.
Despite the advances in diagnostic and therapeutic techniques, the 5-year survival rate …

MDM2 is an oncoprotein that inhibits p53 tumour-suppressor protein. Amplification of the
MDM2 gene and overexpression of its protein have been observed in some human …

The p53 pathway has been extensively studied for its role in carcinogenesis. Disruption of
the pathway occurs in more than half of all cancers, often leading to a worse prognosis for …