Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …

Neuropeptide Y (NPY) exerts a powerful orexigenic effect in the hypothalamus. However,
extra-hypothalamic nuclei also produce NPY, but its influence on energy homeostasis is …

The emergence of the bilateral embryonic body axis from a symmetrical egg has been a
long-standing question in developmental biology. Historical and modern experiments point …

Gene regulatory networks controlling functional activities of spatially and temporally distinct
endodermal cell populations in the early mouse embryo remain ill defined. The T-box …

The ZIC2 transcription factor is one of the most commonly mutated genes in
Holoprosencephaly (HPE) probands. HPE is a severe congenital defect of forebrain …

Excess caloric intake results in increased fat accumulation and an increase in energy
expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms …

Chronic stress fuels the consumption of palatable food and can enhance obesity
development. While stress-and feeding-controlling pathways have been identified, how …

Although best known for their involvement in modulating nociception, Neuropeptide FF
(NPFF) group peptides have been suggested to fulfil a variety of biological functions such as …

Cocaine-and amphetamine-regulated transcript (CART) is widely expressed in the
hypothalamus and an important regulator of energy homeostasis; however, the specific …

The initial landmark of anterior–posterior (A–P) axis formation in mouse embryos is the distal
visceral endoderm, DVE, which expresses a series of anterior genes at embryonic day 5.5 …