With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …

Rapid and sophisticated improvements in molecular analysis have allowed us to sequence
whole human genomes as well as cancer genomes, and the findings suggest that we may …

Cancer progression in humans is difficult to infer because we do not routinely sample
patients at multiple stages of their disease. However, heterogeneous breast tumors provide …

Using the technique of differential cDNA library screening, a cDNA clone was isolated from
an estrogen receptor (ER)-positive breast carcinoma cell line (MCF7) cDNA library based …

Background The humanized anti-HER-2 monoclonal antibody trastuzumab (Herceptin®) is a
new treatment modality for metastatic breast cancer, the efficacy of which is directly …

The steady-state levels of many mRNAs are determined in part by their turnover rates.
Turnover rates, in turn, are usually controlled by proteins that bindcis-acting sequence …

Comparative genomic hybridization (CGH) reveals DNA sequence copy number changes
that are shared among the different cell subpopulations present in a tumor and may help to …

In human carcinomas, especially breast cancer, chromosome arm 8p is frequently involved
in complex chromosomal rearrangements that combine amplification at 8p11-12, break in …

Drug‐induced DNA demethylation in normal human cells and inherited localized
hypomethylation in mitogen‐stimulated lymphocytes from patients with a rare recessive …

Advances in whole genome amplification and next-generation sequencing methods have
enabled genomic analyses of single cells, and these techniques are now beginning to be …