Genetic and biological hallmarks of colorectal cancer

J Li, X Ma, D Chakravarti, S Shalapour… - Genes & …, 2021 - genesdev.cshlp.org
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer

J Bian, M Dannappel, C Wan, R Firestein - Cells, 2020 - mdpi.com
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

[HTML][HTML] The regulation of β-catenin activity and function in cancer: therapeutic opportunities

S Shang, F Hua, ZW Hu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …

Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex

X Su, J Ma, X Wei, P Cao, D Zhu, W Chang, Z Liu… - Science, 2017 - science.org
In plants, the photosynthetic machinery photosystem II (PSII) consists of a core complex
associated with variable numbers of light-harvesting complexes II (LHCIIs). The …

Can we safely target the WNT pathway?

M Kahn - Nature reviews Drug discovery, 2014 - nature.com
WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

The many faces and functions of β‐catenin

T Valenta, G Hausmann, K Basler - The EMBO journal, 2012 - embopress.org
β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

Wnt signaling in cancer

P Polakis - Cold Spring Harbor perspectives in biology, 2012 - cshperspectives.cshlp.org
Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology.
From the earliest observation that Wnt overexpression could lead to malignant …

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

ME Fernandez-Sanchez, S Barbier, J Whitehead… - Nature, 2015 - nature.com
The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces
such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper …

Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue

GS Karagiannis, T Poutahidis, SE Erdman… - Molecular cancer …, 2012 - AACR
Neoplastic cells recruit fibroblasts through various growth factors and cytokines. These
“cancer-associated fibroblasts”(CAF) actively interact with neoplastic cells and form a …

Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin

AE Shyer, AR Rodrigues, GG Schroeder… - Science, 2017 - science.org
The spacing of hair in mammals and feathers in birds is one of the most apparent
morphological features of the skin. This pattern arises when uniform fields of progenitor cells …