[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
Drug-induced QT interval prolongation: mechanisms and clinical management
S Nachimuthu, MD Assar… - Therapeutic advances in …, 2012 - journals.sagepub.com
The prolonged QT interval is both widely seen and associated with the potentially deadly
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …
potential. Some of the K+ channels are primarily responsible for early repolarization …
Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic
LM Hondeghem, L Carlsson, G Duker - Circulation, 2001 - Am Heart Assoc
Background—Prolongation of action potential duration (APD) is considered a major
antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic …
antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic …
[PDF][PDF] Policy Conference
W Haverkamp, G Breithardt, AJ Cammm… - European Heart …, 2000 - escardio.org
The scientific and clinical basis of drug-induced QT prolongation and proarrhythmia was
summarized by formal presentations. The speakers were chosen for their particular …
summarized by formal presentations. The speakers were chosen for their particular …
Restricting Excessive Cardiac Action Potential and QT Prolongation: A Vital Role for IKs in Human Ventricular Muscle
Background—Although pharmacological block of the slow, delayed rectifier potassium
current (I Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action …
current (I Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action …
Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier …
NK Jurkiewicz, MC Sanguinetti - Circulation research, 1993 - Am Heart Assoc
Class III antiarrhythmic agents act by selective prolongation of cardiac action potential
duration (APD). Methanesulfonanilide class III agents (eg, E-4031 and dofetilide) are …
duration (APD). Methanesulfonanilide class III agents (eg, E-4031 and dofetilide) are …
Evidence for Two Components of Delayed Rectifier K+ Current in Human Ventricular Myocytes
Previous voltage-clamp studies have suggested that the delayed rectifier current (IK) is small
or absent in the human ventricle and, when present, consists only of the rapid component …
or absent in the human ventricle and, when present, consists only of the rapid component …
Extracellular Potassium Modulation of Drug Block of IKr Implications for Torsade de Pointes and Reverse Use-Dependence
Background Torsade de pointes often occurs with underlying hypokalemia and bradycardia.
A common effect of many drugs producing torsade de pointes is block of the rapidly …
A common effect of many drugs producing torsade de pointes is block of the rapidly …
The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications: report on a Policy Conference of the European …
W Haverkamp, G Breithardt, AJ Camm… - Cardiovascular …, 2000 - academic.oup.com
Drugs. Clinical and Regulatory Implications was held at the conference. It is based on
written reports composed by the European Heart House in Sophia Antipolis, France, on the …
written reports composed by the European Heart House in Sophia Antipolis, France, on the …