Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

Triple-negative breast cancer (TNBC) is an aggressive breast type of cancer with no
expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal …

The human ATR gene encodes a kinase that is activated by DNA damage and replication
stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR …

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian
tissues. It plays a very critical role in many pathophysiological processes in the body. It can …

We used the cancer-intrinsic property of oncogene-induced DNA damage as the base for a
conditional synthetic lethality approach. To target mechanisms important for cancer cell …

Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging
DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints …

Simple Summary Selective killing of cancer cells is privileged mainstream in cancer
treatment and targeted therapy represents the new tool with a potential to pursue this aim. It …

Chemoresistance, radioresistance, and the challenge of achieving complete resection are
major driving forces in the search for more robust and targeted anticancer therapies …

Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …