Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

KS Lee, S Lin, DA Copland, AD Dick, J Liu - Journal of Neuroinflammation, 2021 - Springer
Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

[HTML][HTML] Restoration of vision in blind individuals using bionic devices: a review with a focus on cortical visual prostheses

PM Lewis, HM Ackland, AJ Lowery, JV Rosenfeld - Brain research, 2015 - Elsevier
The field of neurobionics offers hope to patients with sensory and motor impairment.
Blindness is a common cause of major sensory loss, with an estimated 39 million people …

Choroidal neovascularization: mechanisms of endothelial dysfunction

NJY Yeo, EJJ Chan, C Cheung - Frontiers in Pharmacology, 2019 - frontiersin.org
Many conditions affecting the heart, brain, and even the eyes have their origins in blood
vessel pathology, underscoring the role of vascular regulation. In age-related macular …

Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration

A Alaimo, GG Liñares, JM Bujjamer, RM Gorojod… - Archives of …, 2019 - Springer
Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by
a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a …

Challenges and opportunities for drug delivery to the posterior of the eye

FJ Cabrera, DC Wang, K Reddy, G Acharya… - Drug discovery today, 2019 - Elsevier
Highlights•The development of efficacious ocular drug delivery systems to treat diseases of
the back of the eye faces many challenges due to the unique anatomy and physiology of the …

Two-photon polymerized poly (caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility

JR Thompson, KS Worthington, BJ Green, NK Mullin… - Acta biomaterialia, 2019 - Elsevier
Cell replacement therapies are often enhanced by utilizing polymer scaffolds to improve
retention or direct cell orientation and migration. Obstacles to refinement of such polymer …

Ocular therapeutics and molecular delivery strategies for neovascular age-related macular degeneration (Namd)

A Sarkar, V Junnuthula, S Dyawanapelly - International Journal of …, 2021 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of vision loss in geriatric
population. Intravitreal (IVT) injections are popular clinical option. Biologics and small …

Metformin, a potential role in age-related macular degeneration: a systematic review and meta-analysis

DF Romdhoniyyah, SP Harding, CP Cheyne… - Ophthalmology and …, 2021 - Springer
Background Currently, no generally approved medical treatment can delay the onset of age-
related macular degeneration (AMD) or slow the progression of degenerative changes …

Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium

AV Kuznetsova, AM Kurinov… - Journal of …, 2014 - Wiley Online Library
The retinal pigment epithelium (RPE) plays a key role in the development of many eye
diseases leading to visual impairment and even blindness. Cell culture models of …

[HTML][HTML] Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells

X Chen, R Han, P Hao, L Wang, M Liu, M Jin… - Biomedicine & …, 2018 - Elsevier
Backgrounds Chronic inflammation in retinal pigment epithelial (RPE) cells is related to the
pathogenesis of retinal inflammatory blind causing diseases such as age-related macular …