Characterization and culture of human embryonic stem cells

LM Hoffman, MK Carpenter - Nature biotechnology, 2005 - nature.com
Human embryonic stem cells have been defined as self-renewing cells that can give rise to
many types of cells of the body. How and whether these cells can be manipulated to replace …

The production and directed differentiation of human embryonic stem cells

A Trounson - Endocrine reviews, 2006 - academic.oup.com
Human embryonic stem cells (hESCs) are being rapidly produced from chromosomally
euploid, aneuploid, and mutant human embryos that are available from in vitro fertilization …

The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional …

L Armstrong, O Hughes, S Yung… - Human molecular …, 2006 - academic.oup.com
Understanding the molecular mechanism by which pluripotency is maintained in human
embryonic stem cells (hESC) is important for the development of improved methods to …

Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells

M Drukker, H Katchman, G Katz… - Stem …, 2006 - academic.oup.com
Differentiated cell types derived from human embryonic stem cells (hESCs) may serve in the
future to treat various human diseases. A crucial step toward their successful clinical …

Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells

JC Rivera-Mulia, Q Buckley, T Sasaki… - Genome …, 2015 - genome.cshlp.org
Duplication of the genome in mammalian cells occurs in a defined temporal order referred to
as its replication-timing (RT) program. RT changes dynamically during development …

Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells

P Dvorak, D Dvorakova, S Koskova, M Vodinska… - Stem …, 2005 - academic.oup.com
Although the detection of several components of the fibroblast growth factor (FGF) signaling
pathway in human embryonic stem cells (hESCs) has been reported, the functionality of that …

Engineering bone tissue from human embryonic stem cells

D Marolt, IM Campos, S Bhumiratana… - Proceedings of the …, 2012 - National Acad Sciences
In extensive bone defects, tissue damage and hypoxia lead to cell death, resulting in slow
and incomplete healing. Human embryonic stem cells (hESC) can give rise to all specialized …

Human embryonic stem cells: prospects for development

MF Pera, AO Trounson - 2004 - journals.biologists.com
It is widely anticipated that human embryonic stem (ES) cells will serve as an experimental
model for studying early development in our species, and, conversely, that studies of …

Differentiation of human embryonic stem cells to dopaminergic neurons in serum‐free suspension culture

TC Schulz, SA Noggle, GM Palmarini, DA Weiler… - Stem …, 2004 - academic.oup.com
The use of human embryonic stem cells (hESCs) as a source of dopaminergic neurons for
Parkinson's disease cell therapy will require the development of simple and reliable cell …

Neural differentiation of human embryonic stem cells

SK Dhara, SL Stice - Journal of cellular biochemistry, 2008 - Wiley Online Library
Availability of human embryonic stem cells (hESC) has enhanced human neural
differentiation research. The derivation of neural progenitor (NP) cells from hESC facilitates …