Protein post-translational modifications (PTMs) play an important role in different cellular
processes. In view of the importance of PTMs in cellular functions and the massive data …

The activation of the zygotic genome constitutes an essential process during early
embryogenesis that determines the overall progression of embryonic development. Zygotic …

Stem cells with the capacity of self-renewal and differentiation play pivotal roles in normal
tissues and malignant tumors. Whereas stem cells are supposed to be genetically identical …

The rearrangement and expression of the immunoglobulin μ heavy chain (Igh) gene require
communication of the intragenic Eμ and 3′ regulatory region (RR) enhancers with the …

Embryonic stem cells possess the remarkable ability to self-organize into blastocyst-like
structures upon induction. These stem cell-based embryo models serve as invaluable …

Triple-negative breast cancer (TNBC) is the most aggressive subtype with limited effective
therapies because of the absence of definitive targets. Here, we demonstrate that the …

Several studies have confirmed that exosomes containing microRNAs (miRNAs) from the
aseptic inflammatory microenvironment play an important role in bone remodeling. But the …

Adipose tissue regulates energy homeostasis and metabolic function, but its adaptability is
impaired in obesity. In this study, we investigate the impact of acute PPARγ agonist …

The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its
influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and …

The modification of proteins by s mall u biquitin-related mo difier (SUMO) molecules,
SUMOylation, is a key post-translational modification involved in a variety of biological …