A functional network of blood vessels is essential for organ growth and homeostasis, yet
how the vasculature matures and maintains homeostasis remains elusive in live mice. By …

Red blood cell velocity (RBCv), cerebral blood flow (CBF), and volume (CBV) are three key
parameters when describing brain hemodynamics. Functional ultrasound imaging is a …

Nonlinear microscopy is a technique that utilizes nonlinear interactions between light and
matter to image fluorescence and scattering phenomena in biological tissues. Very high …

A coherent anti-Stokes Raman scattering (CARS)-based multimodality microscopy system
was developed using a single Ti: sapphire femtosecond laser source for biological imaging …

Studying blood microcirculation is vital for gaining insights into vascular diseases. Blood
flow imaging in deep tissue is currently achieved by acute administration of fluorescent dyes …

Neuronal nitric oxide (NO) synthase (nNOS), a Ca2+ dependent enzyme, is expressed by
distinct populations of neocortical neurons. Although neuronal NO is well known to …

The pial vasculature is the sole source of blood supply to the neocortex. The brain is
contained within the skull, a vascularized bone marrow with a unique anatomical connection …

Comprehensive understanding of interconnected networks within the brain requires access
to high resolution information within large field of views and over time. Currently, methods …

Mapping red blood cells (RBCs) flow and oxygenation is of key importance for analyzing
brain and tissue physiology. Current microscopy methods are limited either in sensitivity or …

Whole-brain irradiation (WBI, also known as whole-brain radiation therapy) is a mainstay
treatment modality for patients with multiple brain metastases. It is also used as a …