Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The current obesity pandemic results from a physiological imbalance in which energy intake
chronically exceeds energy expenditure (EE), and prevention and treatment strategies …

Excessive fat accumulation in the body causes overweight and obesity. To date, research
has confirmed that there are two types of adipose tissue with opposing functions: lipid …

The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treat obesity and metabolic diseases. Beyond its …

Purpose Brown adipose tissue (BAT) activation in humans has gained interest as a potential
target for treatment of obesity and insulin resistance. In rodents, BAT is primarily induced …

The circadian clock is a cell-autonomous transcription–translation feedback mechanism that
anticipates and adapts physiology and behavior to different phases of the day. A variety of …

The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …

Background Accumulating evidence links brown adipose tissue (BAT) to increased cold-
induced energy expenditure (CIEE) and regulation of lipid metabolism in humans. BAT has …

β-adrenergic receptor (β-AR) signaling plays predominant roles in modulating energy
expenditure by triggering lipolysis and thermogenesis in adipose tissue, thereby conferring …

Bariatric surgery (BS) procedures are actually the most effective intervention to help subjects
with severe obesity achieve significant and sustained weight loss. White adipose tissue …