Integrated microfluidic devices for point-of-care detection of bio-analytes and disease

PP Behera, N Kumar, M Kumari, S Kumar… - Sensors & …, 2023 - pubs.rsc.org
Micro-and nanofluidics have enabled the possibility of miniaturized analytical systems,
which are commonly known as lab-on-a-chip (LOC) devices. One of the clear benefits of …

[PDF][PDF] Actuation for flexible and stretchable microdevices

U Roshan, A Mudugamuwa, H Cha, S Hettiarachchi… - Lab Chip, 2024 - scholar.archive.org
Over the past decades, device miniaturisation, flexibility, and stretchability have received
increasing attention to enhance portability and wearability, overcome dimensional …

Actuation for flexible and stretchable microdevices

URT Arachchige, A Mudugamuwa, H Cha… - Lab on a Chip, 2024 - pubs.rsc.org
Flexible and stretchable microdevices incorporate highly deformable structures, facilitating
precise functionality at the micro-and millimetre scale. The flexible microdevices have …

Point-of-care devices for the detection of biomarkers of periprosthetic joint infection: State of the art and future perspectives

V Mazzaracchio, R Vitiello, G Maccauro… - TrAC Trends in Analytical …, 2024 - Elsevier
One of the main issues in the management of periprosthetic joint infection (PJI) is related to
the correct diagnosis. Current guidelines for PJI infection are based on the 2018 …

A paper-based aptamer-sandwich assay for detection of HNP 1 as a biomarker for periprosthetic joint infections on an integrated microfluidic platform

R Gandotra, FC Kuo, MS Lee, GB Lee - Analytica Chimica Acta, 2023 - Elsevier
Background Total joint arthroplasty (TJA) has significantly improved the quality of life for
millions suffering from end-stage arthritis. However, periprosthetic joint infections (PJI) …

Fully Integrated Microfluidic Device for Magnetic Bead Manipulation to Assist Rapid Reaction and Cleaning

Z Yang, M Ren, Y Li, M Zhou, J Peng, S Lin… - Analytical …, 2023 - ACS Publications
Methods to manipulate magnetic beads are essential factors to determine the efficiency and
dimension of an in vitro diagnostic system. Currently, using movable permanent magnets …

Advancing the Diagnosis of Periprosthetic Joint Infections: Integrated Microfluidic Platform for Alpha-Defensins-Specific Aptamer Selection and Its Analytical …

R Gandotra, HB Wu, FC Kuo, MS Lee, GB Lee - ACS sensors, 2024 - ACS Publications
Periprosthetic joint infections (PJIs) pose a significant challenge in orthopedic surgery,
particularly total joint arthroplasty (TJA), due to the potential for implant failure and increased …

A dual-aptamer sandwich assay by detection of C-reactive protein in synovial fluid on an integrated microfluidic system for diagnosis of periprosthetic joint infection

TW Chen, CH Wang, FC Kuo, MS Lee… - Sensors and Actuators B …, 2025 - Elsevier
Diagnosing periprosthetic joint infection (PJI) in equivocal cases is always challenging.
Synovial fluid (SF) C-reactive protein (CRP) levels have been reported as a surrogate to …

A Dual-Aptamer Sandwich Assay for Detection of C-Reactive Protein on an Integrated Microfluidic System

TW Chen, CH Wang, GB Lee - 2024 IEEE 19th International …, 2024 - ieeexplore.ieee.org
This study reported a novel magnetic-bead-based dual-aptamer assay for C-reactive protein
(CRP) diagnosis, which may replace antibodies in a traditional enzyme-linked …