Epilepsy is a disease characterized by abnormal brain activity and a predisposition to
generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and …

Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …

INTRODUCTION The nine subtypes of mammalian voltage-gated sodium (Nav) channels,
Nav1. 1 to Nav1. 9, are responsible for the initiation and propagation of action potentials in …

INTRODUCTION Voltage-gated sodium (Nav) channels are responsible for the generation
and propagation of action potentials in excitable cells. They undergo voltage-dependent …

Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …

INTRODUCTION Members of the voltage-gated sodium (Nav) channel family are critical
contributors to electrical signaling. Accordingly, they are targets of drugs, toxins, and …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Nav1. 5 is the primary voltage-gated Na+ (Nav) channel in the heart. Mutations of Nav1. 5
are associated with various cardiac disorders exemplified by the type 3 long QT syndrome …

Voltage-gated sodium channels are critical for the generation and propagation of electrical
signals in most excitable cells. Activation of Na+ channels initiates an action potential, and …

Voltage-gated sodium ion channel subtype 1.7 (NaV1. 7) is a high interest target for the
discovery of non-opioid analgesics. Compelling evidence from human genetic data …