The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …

DNA methylation is a major epigenetic process that regulates chromatin structure which
causes transcriptional activation or repression of genes in a context-dependent manner. In …

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …

Low muscle strength is an important heritable indicator of poor health linked to morbidity and
mortality in older people. In a genome-wide association study meta-analysis of 256,523 …

Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about
how EBOV usurps host pathways during infection. To address this, we used affinity tag …

The key RNA sequence elements and protein factors necessary for 3′ processing of
polyadenylated mRNA precursors are well known. Recent studies, however, have …

DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-
directed repair (HDR) and alternative end joining (Alt-EJ). Here, we found that GRB2, crucial …

To complete the duplication of large genomes efficiently, mechanisms have evolved that
coordinate DNA unwinding with DNA synthesis and provide quality control measures prior to …

Short stature is a common presentation to paediatric endocrinologists. After exclusion of
major endocrine or systemic disease, most children with short stature are diagnosed based …

Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex.
Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb …