The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

Smooth muscle cell (SMC) contraction is controlled by the Ca2+ and Rho kinase signalling
pathways. While the SMC Rho kinase system seems to be reasonably constant, there is …

BK large conductance voltage-and calcium-activated potassium channels respond to
elevations in intracellular calcium and membrane potential depolarization, braking …

The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and
questions concerning its roles, especially as these change with development, disease, and …

The large conductance calcium-and voltage-activated K+ channel (KCa1. 1, BK, MaxiK) is
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …

Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology,
both in neuronal and non-neuronal cells and tissues. Through negative feedback between …

Contraction and relaxation of the detrusor smooth muscle (DSM), which makes up the wall of
the urinary bladder, facilitates the storage and voiding of urine. Several families of K+ …

The normal physiological contraction of the urinary bladder, which is required for voiding, is
predominantly mediated by muscarinic receptors, primarily the M 3 subtype, with the M 2 …

The physiological functions of the urinary bladder are to store and periodically expel urine.
These tasks are facilitated by the contraction and relaxation of the urinary bladder smooth …

Airway smooth muscle (ASM) cells exhibit phenotype plasticity that is under control of
external stimuli such as growth factors and the extracellular matrix, and is regulated by a …