COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

Biomarkers in long COVID-19: A systematic review

YJ Lai, SH Liu, S Manachevakul, TA Lee… - Frontiers in …, 2023 - frontiersin.org
Purpose Long COVID, also known as post-acute sequelae of COVID-19, refers to the
constellation of long-term symptoms experienced by people suffering persistent symptoms …

Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality

HM Al-Kuraishy, AI Al-Gareeb, HA Al-Hussaniy… - International …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (Covid-19) is a worldwide infectious disease caused by
severe acute respiratory coronavirus 2 (SARS-CoV-2). In severe SARS-CoV-2 infection …

Human immune diversity: from evolution to modernity

A Liston, S Humblet-Baron, D Duffy, A Goris - Nature immunology, 2021 - nature.com
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

N Potere, MG Del Buono, R Caricchio, PC Cremer… - …, 2022 - thelancet.com
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

Neuroinflammation and COVID-19

A Vanderheiden, RS Klein - Current opinion in neurobiology, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of
respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms …

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

L Ruhl, I Pink, JF Kühne, K Beushausen… - Signal transduction and …, 2021 - nature.com
The systemic processes involved in the manifestation of life-threatening COVID-19 and in
disease recovery are still incompletely understood, despite investigations focusing on the …

[HTML][HTML] NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel

N Krinsky, S Sizikov, S Nissim, A Dror, A Sas… - Journal of Thrombosis …, 2023 - Elsevier
Background COVID-19 severity and its late complications continue to be poorly understood.
Neutrophil extracellular traps (NETs) form in acute COVID-19, likely contributing to morbidity …

Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2

M Venet, MS Ribeiro, E Décembre, A Bellomo… - Nature …, 2023 - nature.com
Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2
infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant …