Cardiac cell therapy holds a real promise for improving heart function and especially of the
chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

For the past decades, heart diseases remain the leading cause of death worldwide. In the
adult mammalian heart, damaged cardiomyocytes will be replaced by non-contractile fibrotic …

Abstract Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for
the development of engineered cardiac tissue, facilitating high-throughput testing in drug …

Tissue engineering to develop alternatives for the maintenance, restoration, or
enhancement of injured tissues and organs is gaining more and more attention. In tissue …

Electrospun nanofibers have been extensively explored as a class of scaffolding materials
for tissue regeneration, because of their unique capability to mimic some features and …

Cardiovascular diseases (CVDs) present a significant threat to health, with traditional
pharmaceuticals for their treatment being hindered by inefficiencies due to non-targeted …

Recent innovations in differentiating cardiomyocytes from human induced pluripotent stem
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …

Regenerative medicine aims to engineer tissue constructs that can recapitulate the
functional and structural properties of native organs. Most novel regenerative therapies are …

Polylactide acid (PLA), as an FDA-approved biomaterial, has been widely applied due to its
unique merits, such as its biocompatibility, biodegradability, and piezoelectricity. Numerous …