Mitochondrial membrane lipids in the regulation of bioenergetic flux
Oxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …
Integrated multi-omics for rapid rare disease diagnosis on a national scale
Critically ill infants and children with rare diseases need equitable access to rapid and
accurate diagnosis to direct clinical management. Over 2 years, the Acute Care Genomics …
accurate diagnosis to direct clinical management. Over 2 years, the Acute Care Genomics …
Mitochondrial biology and dysfunction in secondary mitochondrial disease
Mitochondrial diseases are a broad, genetically heterogeneous class of metabolic disorders
characterized by deficits in oxidative phosphorylation (OXPHOS). Primary mitochondrial …
characterized by deficits in oxidative phosphorylation (OXPHOS). Primary mitochondrial …
[HTML][HTML] Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
Summary Acyl-protein thioesterases 1 and 2 (APT1 and APT2) reverse S-acylation, a
potential regulator of systemic glucose metabolism in mammals. Palmitoylation proteomics …
potential regulator of systemic glucose metabolism in mammals. Palmitoylation proteomics …
Interorganelle phospholipid communication, a house not so divided
The presence of membrane-bound organelles with specific functions is one of the main
hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that …
hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that …
Mitochondrial membrane synthesis, remodelling and cellular trafficking
Mitochondria are dynamic cellular organelles with complex roles in metabolism and
signalling. Primary mitochondrial disorders are a group of approximately 400 monogenic …
signalling. Primary mitochondrial disorders are a group of approximately 400 monogenic …
Mitochondrial phospholipid metabolism in health and disease
Studies of rare human genetic disorders of mitochondrial phospholipid metabolism have
highlighted the crucial role that membrane phospholipids play in mitochondrial …
highlighted the crucial role that membrane phospholipids play in mitochondrial …
Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier
Lipid-protein interactions play a multitude of essential roles in membrane homeostasis.
Mitochondrial membranes have a unique lipid-protein environment that ensures …
Mitochondrial membranes have a unique lipid-protein environment that ensures …
Unique architectural features of mammalian mitochondrial protein synthesis
Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with
that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has …
that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has …
Bridging clinical care and research in Ontario, Canada: Maximizing diagnoses from reanalysis of clinical exome sequencing data
We examined the utility of clinical and research processes in the reanalysis of publicly‐
funded clinical exome sequencing data in Ontario, Canada. In partnership with eight sites …
funded clinical exome sequencing data in Ontario, Canada. In partnership with eight sites …