Introduction: The effective treatment of autoimmune diseases remains a challenge. Voltage-
gated potassium Kv1. 3 channels, which are expressed in lymphocytes, are a new …

Microglia, the central nervous system resident innate immune cells, cluster around Aβ
plaques in Alzheimer's disease (AD). The activation phenotype of these plaque‐associated …

Cancer is the consequence of aberrations in cell growth or cell death. In this scenario,
mitochondria and ion channels play a critical role in regard to cell proliferation, malignant …

There are currently no drugs known to rescue the function of Kv1. 1 voltage-gated potassium
channels carrying loss-of-function sequence variants underlying the inherited movement …

Abstract Treatment of Staphylococcus aureus infections remains very difficult due to its
capacity to survive intracellularly and its multidrug resistance. In this study, the extracellular …

The structural similarity between defensins and scorpion neurotoxins suggests that they
might have evolved from a common ancestor. However, there is no direct experimental …

Human β-defensin 2 enhances IL-1β production and pyroptosis through P2X7-mediated
NLRP3 expression in macrophages Page 1 Human β-defensin 2 enhances IL-1β production …

The classical potassium channel inhibitors are toxin peptides from venomous animals, and
whether there are peptide inhibitors from other species is an open question. Due to both the …

Fungus defensin is a kind of important natural peptide resource, such as plectasin from the
soil fungus Pseudoplectania nigrella with potential application in the antimicrobial peptide …

Compared with earlier more restricted sequencing technologies, identification of rare
disease variants using whole‐genome sequence has the possibility of finding all causative …