Biomarkers of migraine: an integrated evaluation of preclinical and clinical findings

C Demartini, M Francavilla, AM Zanaboni… - International journal of …, 2023 - mdpi.com
In recent years, numerous efforts have been made to identify reliable biomarkers useful in
migraine diagnosis and progression or associated with the response to a specific treatment …

Epigenetic mechanisms involved in the effects of maternal hyperhomocysteinemia on the functional state of placenta and nervous system plasticity in the offspring

AV Arutjunyan, YP Milyutina, AD Shcherbitskaia… - Biochemistry …, 2023 - Springer
According to modern view, susceptibility to diseases, specifically to cognitive and
neuropsychiatric disorders, can form during embryonic development. Adverse factors …

Hyperhomocysteinemia increases cortical excitability and aggravates mechanical hyperalgesia and anxiety in a nitroglycerine-induced migraine model in rats

E Gerasimova, O Yakovleva, D Enikeev, K Bogatova… - Biomolecules, 2022 - mdpi.com
Homocysteine is a sulfur-containing endogenous amino acid leading to neurotoxic effects at
high concentrations. Population studies suggest an association between plasma …

Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization

B Alpay, B Cimen, E Akaydin, H Bolay… - The journal of headache …, 2023 - Springer
Background Migraine headache attacks and accompanying sensory augmentation can be
induced by several agents including levcromakalim (LVC), that is also capable of provoking …

Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats

AV Yakovlev, E Kurmashova, E Gataulina… - Life Sciences, 2023 - Elsevier
Aims Neonatal seizures are severe pathologies which may result in long-term neurological
consequences. High plasma concentrations of homocysteine–hyperhomocysteinemia …

[HTML][HTML] Hypersensitivity of Intrinsically Photosensitive Retinal Ganglion Cells in Migraine Induces Cortical Spreading Depression

E Nagata, M Takao, H Toriumi, M Suzuki… - International Journal of …, 2024 - mdpi.com
Migraine is a complex disorder characterized by episodes of moderate-to-severe, often
unilateral headaches and generally accompanied by nausea, vomiting, and increased …

[HTML][HTML] Chronic Hyperhomocysteinemia Impairs CSD Propagation and Induces Cortical Damage in a Rat Model of Migraine with Aura

E Gerasimova, D Enikeev, A Yakovlev, A Zakharov… - Biomolecules, 2024 - mdpi.com
Hyperhomocysteinemia (hHCY) is a metabolic disorder characterized by elevated levels of
homocysteine in plasma. hHCY correlates with a high risk of migraine headaches …

A Focal Traumatic Injury to the Neonatal Rodent Spinal Cord Causes an Immediate and Massive Spreading Depolarization Sustained by Chloride Ions, with Transient …

A Mohammadshirazi, GL Mazzone… - Cellular and Molecular …, 2025 - Springer
In clinics, physical injuries to the spinal cord cause a temporary motor areflexia below lesion,
known as spinal shock. This topic is still underexplored due to the lack of preclinical spinal …

Implications of high homocysteine levels in migraine pain: An experimental study of the excitability of peripheral meningeal afferents in rats with …

E Ermakova, K Shaidullova, O Gafurov… - … : The Journal of …, 2024 - Wiley Online Library
Objectives Investigation of chronic homocysteine action on the excitability and N‐methyl‐D‐
aspartate (NMDA) sensitivity of the peripheral trigeminovascular system of rats. Background …

A focal traumatic injury to the spinal cord causes an immediate and massive spreading depolarization sustained by chloride ions, with transient network dysfunction …

A Mohammadshirazi, GL Mazzone, BA Zylberberg… - bioRxiv, 2024 - biorxiv.org
In clinics, physical injuries to the spinal cord cause a temporary motor areflexia below lesion,
known as spinal shock. This topic is still underexplored due to the lack of preclinical SCI …