Cytokines are important immunotherapeutics with approved drugs for the treatment of
human cancers. However, systemic administration of cytokines often fails to achieve …

Abstract Interleukin-27 (IL-27), a member of the IL-6/IL-12 family, has diverse regulatory
functions in various immune responses, and is recognised as a potent agonist and …

The delivery of lipid nanoparticle (LNP)-based mRNA therapeutics has captured the
attention of the vaccine research community as an innovative and versatile tool for treating a …

The treatment of patients with advanced-stage solid tumours typically involves a
multimodality approach (including surgery, chemotherapy, radiotherapy, targeted therapy …

Inactivating mutations of Foxp3, the master regulator of regulatory T cell development and
function, lead to immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) …

Research for tumor treatment with significant therapy effects and minimal side-effects has
been widely carried over the past few decades. Different drug forms have received a lot of …

Background. Stimulation of myeloid-derived suppressor cell (MDSC) formation represents a
potential curative therapeutic approach for graft-versus-host disease (GVHD), which …

Viral vectors have been frequently applied for cancer therapy including adenoviruses,
adeno-associated viruses, herpes simplex viruses, retroviruses, lentiviruses, alphaviruses …

Disclosed herein are diamino lipid (dal) compounds and pharmaceutical compositions
including mRNA encoding an immunotherapeutic agent and methods of making and use …