Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

C Lebeaupin, D Vallée, Y Hazari, C Hetz, E Chevet… - Journal of …, 2018 - Elsevier
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

Role of endoplasmic reticulum stress in the anticancer activity of natural compounds

P Limonta, RM Moretti, M Marzagalli, F Fontana… - International journal of …, 2019 - mdpi.com
Cancer represents a serious global health problem, and its incidence and mortality are
rapidly growing worldwide. One of the main causes of the failure of an anticancer treatment …

New visions on natural products and cancer therapy: autophagy and related regulatory pathways

A Martelli, M Omrani, M Zarghooni, V Citi, S Brogi… - Cancers, 2022 - mdpi.com
Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …

Endoplasmic reticulum stress and autophagy in the pathogenesis of non-alcoholic fatty liver disease (NAFLD): current evidence and perspectives

CM Flessa, I Kyrou, N Nasiri-Ansari, G Kaltsas… - Current obesity …, 2021 - Springer
Abstract Purpose of Review Non-alcoholic fatty liver disease (NAFLD) is one of the most
common causes of chronic liver disease with rising prevalence worldwide. Herein, we …

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

E Saunier, S Antonio, A Regazzetti, N Auzeil… - Scientific reports, 2017 - nature.com
Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-
inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in …

Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line

JR Heo, SM Kim, KA Hwang… - … journal of molecular …, 2018 - spandidos-publications.com
Resveratrol, a dietary product present in grapes, vegetables and berries, regulates several
signaling pathways that control cell division, cell growth, apoptosis and metastasis …

[HTML][HTML] Applications of resveratrol in the treatment of gastrointestinal cancer

M Roshani, A Jafari, A Loghman, AH Sheida… - Biomedicine & …, 2022 - Elsevier
Natural product compounds have lately attracted interest in the scientific community as a
possible treatment for gastrointestinal (GI) cancer, due to their anti-inflammatory and …

ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells

S Gu, C Chen, X Jiang, Z Zhang - Chemico-biological interactions, 2016 - Elsevier
Although it is well documented that endoplasmic reticulum (ER) stress and mitochondrial
dysfunction are associated with apoptosis, little is known about whether they are involved in …

[HTML][HTML] Resveratrol specifically kills cancer cells by a devastating increase in the Ca2+ coupling between the greatly tethered endoplasmic reticulum and …

CT Madreiter-Sokolowski, B Gottschalk… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Resveratrol and its derivate piceatannol are known to induce cancer cell-
specific cell death. While multiple mechanisms of actions have been described including the …

[HTML][HTML] 17β-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance

BM Galmés-Pascual, MR Martínez-Cignoni… - Free Radical Biology …, 2020 - Elsevier
The prevalence and severity of nonalcoholic fatty liver disease (NAFLD) is higher in men
and postmenopausal women compared to premenopausal women, suggesting a protective …