An increasing body of evidence supports the concept that host‐produced PGE2 mediates
much of the tissue destruction that occurs in periodontal disease. PGE2 levels within the …

Assessment of risk for periodontitis is still in its infancy. Nevertheless, a sufficient amount of
dependable information exists to begin using risk assessment in the day to day practice of …

Tumor necrosis factor α (TNFα) is a potent immunomodulator and proinflammatory cytokine
that has been implicated in the pathogenesis of autoimmune and infectious diseases. For …

In the present study we searched for restriction fragment length polymorphisms (RFLP) in
the human interleukin‐1β (IL‐lβ) gene and for correlations to monocyte (Mo) function in non …

Background: Because of several similar features in the pathobiology of periodontitis and
rheumatoid arthritis, in a previous study we proposed a possible relationship between the …

Since a dysregulated synthesis of tumor necrosis factor alpha (TNF-alpha) may be involved
in the pathogenesis of autoimmune diseases, it was of interest to precisely locate the …

Tumor necrosis factor α (TNFα) is a potent inflammatory cytokine. In human, the TNFα gene
is located within the highly polymorphic major histocompatibility complex (MHC) region on …

TNF‐α is a proinflammatory cytokine that has been implicated in the severity of different
immune‐regulated diseases including autoimmune diseases and transplantation. The gene …

The genomic region encompassing the Major Histocompatibility Complex (MHC) contains
polymorphic frozen blocks which have developed by local imperfect sequential duplication …

Rheumatoid arthritis and chronic periodontitis are both chronic inflammatory diseases
characterized by an exacerbated inflammatory reaction that leads to destruction of bone and …